Surface-modified WE43 magnesium alloys for reduced degradation and superior biocompatibility

WE43 magnesium alloy was modified using surface mechanical attrition treatment (SMAT) and characterized to evaluate the influence of sub-micron modification on degradation rate in vitro behavior. Modified for wettability, hardness, roughness, rate, biocompatibility, antibacterial activity as per ASTM standards. The treated substrates proved have a significant decrease profile by creating micro pockets oxidation channels reducing total delamination comparison conventional heterogeneous oxide layer formed untreated substrate surface. Biocompatibility studies showed that this did not induce any toxicity human fetal osteoblast (hFOB) cells demonstrated cell proliferation enhanced calcium deposition. In fact, results between 7th day 14th culture, there an eight time increase deposition surface-treated alloy. Bacterial adhesion were carried out Staphylococcus aureus methicillin-resistant aureus. both control samples toxic bacteria with more dead cells. Hence, has developed highly potential orthopedic decreased biodegradability simultaneously properties good growth faster bone growth.